New Biomaterial Could Revolutionise Knee Surgery

Scientists at Northwestern University (NU) in Evanston, Illinois have developed a bioactive material that can regenerate cartilage in knee joints, offering possible relief for those suffering from related conditions.

The material, which resembles stretchy glue, was developed by study lead Samuel Stupp and his fellow NU researchers, and consists of a complicated biological mix of modified substances and joint fluid that is naturally found in cartilage.

Included in this biological broth is hyaluronic acid, which is commonly found in skincare products and is naturally present in many body tissues.

In tests conducted on sheep with cartilage defects in their stifle joints – which share similarities with human knees – the material showed promising results. After six months, the team observed the growth of new, high-quality cartilage containing natural biopolymers such as collagen II and proteoglycans, which are crucial for pain-free joint movement.

The success of this biomaterial in regenerating high-quality cartilage in sheep suggests, if proven effective in humans, it could address a significant clinical need,, providing a solution for those suffering from joint pain and poor mobility due to damaged cartilage.

This innovation could potentially prevent the need for invasive knee replacement surgeries, as well as treat conditions like osteoarthritis and sports injuries such as anterior cruciate ligament tears. It can also provide improved long-term mobility and reduce pain without the need for joint reconstruction hardware.

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